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Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 508-511 doi: 10.1007/s11684-015-0418-7

Abstract:

Bile duct injury is a common complication of cholecystectomy.The timing of bile duct injury repair remains controversial.Most patients with bile duct injury present with bile leak and sepsis; thus, early repair is not recommendedPercutaneous drainage of bile and endoscopic stenting are the mainstays of treatment of bile leak becausethey convert acute bile duct injury into a controlled external biliary fistula.

Keywords： bile duct injury     cholecystectomy     laparoscopic cholecystectomy    

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Strategies of minimally invasive treatment for intrahepatic and extrahepatic bile duct stones

Zongming Zhang, Zhuo Liu, Limin Liu, Mengmeng Song, Chong Zhang, Hongwei Yu, Baijiang Wan, Mingwen Zhu, Zixu Liu, Hai Deng, Haiming Yuan, Haiyan Yang, Wenping Wei, Yue Zhao

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 576-589 doi: 10.1007/s11684-017-0536-5

Abstract: duct stones by combining our practical experience were summarized as follows. (1) For intrahepatic bileduct stones, the operation may be selected by laparoscopic liver resection, laparoscopic common bileand common bile duct stones, the surgical approach can be selected as follows: laparoscopic cholecystectomyand extrahepatic bile duct stones, laparoscopic liver resection, choledochoscopy through the hepaticduct stones.

Keywords： laparoscopy     choledochoscopy     duodenoscopy     cholelithiasis     minimally invasive treatment    

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Effects of hydralazine and valproate on the expression of E-cadherin gene and the invasiveness of QBC

Hong LI, Shaoqin CHEN, Yi SHU, Yongjun CHEN, Ying SU, Xin WANG, Shengquan ZOU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 153-157 doi: 10.1007/s11684-009-0034-5

Abstract: To clarify the effect of DNA methylation and histone deacetylase inhibitors on the expression of the E-cadherin gene and the invasiveness of the QBC cells, the QBC cells were separately treated with hydralazine, valproate, or combination of the two drugs. The mRNA expression of E-cadherin was examined with reverse transcription-polymerase chain reaction (RT-PCR), the protein of the gene with Western blotting. The methylation status of the promoter region of the gene was detected with methylation-specific PCR (MSP). The invasiveness of QBC cells was detected with transwell assay. It was found that the promoter region of the E-cadherin gene of QBC cells was hypermethylated. Valproate alone could not contribute to demethylation of the gene, whereas hydralazine could make them to be partly demethylated. However, the methylation status of the gene could be thoroughly reversed by using valproate and hydralazine in combination. What’s more, it was confirmed that the E-cadherin gene of QBC cells could not be transcriptionally reactivated by Valproate alone, whereas hydralazine alone could induce moderate reexpression of the gene. However, using valproate and hydralazine in combination could result in robust reexpression of the E-cadherin gene ( =0.000). Likewise, the invasiveness of the QBC939 cells was sharply decreased by treatment with two drugs in combination and slightly decreased with one drug alone. It could be concluded that the two drugs have synergistic effect on the demethylation and reexpression of the E-cadherin gene of QBC cells, and also on the reduction of the invasiveness of the QBC939 cells.

Keywords： DNA methylation inhibitor     histone deacetylase inhibitor     bile duct carcinoma     E-cadherin    

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Diagnosis and treatment of thyroglossal duct carcinoma: Report of three cases with review of literatures

GAO Yan, CHEN Yan, SUN Zhipeng, GUO Chuanbin, YU Guangyan, ZHAN Yi

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 58-62 doi: 10.1007/s11684-008-0011-4

Abstract: Thyroglossal duct carcinoma, which is usually diagnosed postoperatively, is a rare malignant tumor arisingWe retrospectively reviewed three cases of thyroglossal duct carcinoma diagnosed in Peking UniversityThe constituent ratio of thyroglossal duct carcinoma among surgically excised thyroglossal duct lesionsThe clinical presentation of thyroglossal duct carcinoma was very similar to that of its benign counterpartPrimary thyroglossal duct carcinoma should conform to the following criteria: localization of the carcinoma
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Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 729-746 doi: 10.1007/s11684-022-0978-2

Abstract: of anti-programmed cell death 1 (anti-PD-1) immunotherapy is limited in patients with hepatocellular carcinomaMechanistically, hepatocyte-specific Yap1 knockout (Yap1LKO) maintained bile

Keywords： hepatocellular carcinoma     YAP1     Akkermansia muciniphila     anti-PD-1     dihydroartemisinin     bile acid    

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A giant Müllerian duct cyst in the perineum: a case report

Xianghu Meng, Jihong Liu, Xiao Yu, Shaogang Wang, Cong Liu, Zhangqun Ye

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 440-443 doi: 10.1007/s11684-012-0222-6

Abstract:

The authors present a case report of a giant Müllerian duct cyst in the perineum.Pathologic examination confirmed the presence of a Müllerian duct cyst.Huge Müllerian duct cyst is uncommon in clinic.Treatments of Müllerian duct cysts depend on their sizes and symptoms.

Keywords： Müllerian duct cyst     clinical symptoms     diagnosis    

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Bile acids and their effects on diabetes

Cynthia Rajani, Wei Jia

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 608-623 doi: 10.1007/s11684-018-0644-x

Abstract: Manipulation of bile acid (BA) receptors and the BA pool have been shown to be useful in establishing

Keywords： bile acids     metabolic memory     diabetes     circadian rhythm     bariatric surgery    

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Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 132-142 doi: 10.1007/s11684-022-0938-x

Abstract: Nasopharyngeal carcinoma (NPC) is a malignant tumor that mainly occurs in East and Southeast Asia.

Keywords： nasopharyngeal carcinoma     WGCNA     RFC4     proliferation    

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Artificial Bear Bile: A Novel Approach to Balancing Medical Requirements and Animal Welfare

Yong Li,Yuhong Huang,Nan Feng,Heping Zhang,Jing Qu,Shuanggang Ma,Yunbao Liu,Jiang Li,Shaofeng Xu,Ling Wang,Mi Zhang,Jie Cai,Weiping Wang,Ru Feng,Hang Yu,Bo Yu,Dailiang Liang,Heping Qin,Suxiang Luo,Yanfen Li,

Engineering doi: 10.1016/j.eng.2023.09.017

Abstract: Bear bile has been a valuable and effective medicinal material in traditional Chinese medicine (TCM)Here, we present a new approach for creating artificial bear bile (ABB) as a high-quality and sustainablealternative to natural bear bile.This study addresses the scientific challenges of creating bear bile alternatives through interdisciplinarytechnologies, our research has achieved the environmentally friendly, large-scale production of bear bile

Keywords： Artificial bear bile     Chemical profile     Formula optimization     Pharmacodynamic consistency     Preclinical toxicological    

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The impact of hypoxia in hepatocellular carcinoma metastasis

Carmen Chak-Lui Wong, Alan Ka-Lun Kai, Irene Oi-Lin Ng

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 33-41 doi: 10.1007/s11684-013-0301-3

Abstract:

Hypoxia is a common phenomenon in hepatocellular carcinoma (HCC).

Keywords： hypoxia     hepatocellular carcinoma (HCC)     metastasis     hypoxia-inducible factor (HIF)    

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Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 24-32 doi: 10.1007/s11684-014-0312-8

Abstract: study, OPN was identified as one of the leading genes associated with the metastasis of hepatocellular carcinoma

Keywords： osteopontin (OPN)     hepatocellular carcinoma     metastasis     prognosis     therapeutic target     biomarker     genetic    

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Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic

Min Yu, Zonghai Li

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 509-521 doi: 10.1007/s11684-017-0546-3

Abstract:

Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leading

Keywords： natural killer cell     hepatocellular carcinoma     immunotherapy    

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Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a

Li Ma, Bin Wang, Yuanxiong Long, Hanmin Li

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 191-202 doi: 10.1007/s11684-017-0512-0

Abstract:

Primary hepatic carcinoma (PHC) is a common malignant tumor in China.with meta-analysis aimed to assess the effect of TCM combined with Western therapy on primary hepatic carcinoma

Keywords： traditional Chinese medicine     primary hepatic carcinoma     meta-analysis    

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Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis

Xinsen Xu,Yanyan Zhou,Runchen Miao,Wei Chen,Kai Qu,Qing Pang,Chang Liu

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 183-190 doi: 10.1007/s11684-016-0440-4

Abstract: coexpression network analysis (WGCNA) to gain insights into the molecular aspects of hepatocellular carcinoma

Keywords： hepatocellular carcinoma     coexpression     module     microarray     prognosis    

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Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check

Amy Lee, Fa-Chyi Lee

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 273-283 doi: 10.1007/s11684-019-0728-2

Abstract: In terms of global cancer-related deaths, hepatocellular carcinoma (HCC) has the fourth highest mortality

Keywords： hepatocellular carcinoma     tyrosine kinase inhibitor     check point inhibitor     anti-angiogenesis    

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Title Author Date Type Operation

Bile duct injury repair — earlier is not better

Vinay K. Kapoor

Journal Article

Strategies of minimally invasive treatment for intrahepatic and extrahepatic bile duct stones

Zongming Zhang, Zhuo Liu, Limin Liu, Mengmeng Song, Chong Zhang, Hongwei Yu, Baijiang Wan, Mingwen Zhu, Zixu Liu, Hai Deng, Haiming Yuan, Haiyan Yang, Wenping Wei, Yue Zhao

Journal Article

Effects of hydralazine and valproate on the expression of E-cadherin gene and the invasiveness of QBC

Hong LI, Shaoqin CHEN, Yi SHU, Yongjun CHEN, Ying SU, Xin WANG, Shengquan ZOU

Journal Article

Diagnosis and treatment of thyroglossal duct carcinoma: Report of three cases with review of literatures

GAO Yan, CHEN Yan, SUN Zhipeng, GUO Chuanbin, YU Guangyan, ZHAN Yi

Journal Article

Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma

Journal Article

A giant Müllerian duct cyst in the perineum: a case report

Xianghu Meng, Jihong Liu, Xiao Yu, Shaogang Wang, Cong Liu, Zhangqun Ye

Journal Article

Bile acids and their effects on diabetes

Cynthia Rajani, Wei Jia

Journal Article

Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Journal Article

Artificial Bear Bile: A Novel Approach to Balancing Medical Requirements and Animal Welfare

Yong Li,Yuhong Huang,Nan Feng,Heping Zhang,Jing Qu,Shuanggang Ma,Yunbao Liu,Jiang Li,Shaofeng Xu,Ling Wang,Mi Zhang,Jie Cai,Weiping Wang,Ru Feng,Hang Yu,Bo Yu,Dailiang Liang,Heping Qin,Suxiang Luo,Yanfen Li,

Journal Article

The impact of hypoxia in hepatocellular carcinoma metastasis

Carmen Chak-Lui Wong, Alan Ka-Lun Kai, Irene Oi-Lin Ng

Journal Article

Osteopontin is a promoter for hepatocellular carcinoma metastasis: a summary of 10 years of studies

Lunxiu Qin

Journal Article

Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic

Min Yu, Zonghai Li

Journal Article

Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a

Li Ma, Bin Wang, Yuanxiong Long, Hanmin Li

Journal Article

Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis

Xinsen Xu,Yanyan Zhou,Runchen Miao,Wei Chen,Kai Qu,Qing Pang,Chang Liu

Journal Article

Medical oncology management of advanced hepatocellular carcinoma 2019: a reality check

Amy Lee, Fa-Chyi Lee

Journal Article